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pentobarbital will decrease the level or influence of brexpiprazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Double brexpiprazole dose about 1-2 months if administered with a robust CYP3A4 inducer.Monoamine oxidase inhibitors (MAOI) could inhibit barbiturate metabolism and lengthen barbiturate outc